Publications — Andreas Brink-Kjær

2026

Physiological Signatures Derived from Wrist Accelerometry Improve Detection of Isolated REM Sleep Behavior Disorder
Andreas Brink-Kjaer, Johanne Niman Abildgaard, Niels Rasmus Lorenzen, Giorgio Ricciardiello Mejia, Kang Hyun Ryu, Salonee Marwaha, Emmanuel Mignot, Joseph R. Winer, Kathleen Poston, Gülçin Benbir Şenel & Emmanuel H. During
medRxiv, 2026Preprint
Part of Wearable screening for isolated REM sleep behavior disorder
Paper
Machine and deep learning in REM sleep behavior disorder: a scoping review and analysis of reporting quality
Andreas Brink-Kjaer, Irene Rechichi, Dario Arnaldi, Olivia Cesarone, Emmanuel During, Simon Feuerstein, Katarina M. Gunter, Birgit Högl, Abubaker Ibrahim, Poul Jennum, Emmanuel Mignot, Gabriella Olmo, Monica Roascio, Ambra Stefani, Qi Tang & Matteo Cesari
Sleep Medicine Reviews, 2026
Paper
Accelerometry-Derived REM Sleep Behavior Disorder Predicts Future Parkinson’s Disease in the UK Biobank
Giorgio Ricciardiello Mejia, Andreas Brink-Kjaer, Lang Liu, Li Zhou, Katarina Gunter, Kang Hyun Ryu, Sajila Wickramaratne, Ankit Parekh, Ziv Gan-Or & Emmanuel During
medRxiv, 2026Preprint
Paper Code
Agentic AI-enabled discovery across large-scale sleep physiology
Rahul Thapa, Umaer Hanif, Robin Guillard, Andreas Brink-Kjaer, Adrien Specht, Matteo Saibene, Magnus Ruud Kjaer, Harrison G. Zhang, Federico Bianchi, Elisabeth Roxane M. Heremans, Eric C. Landsness, Emmanuel Mignot & James Zou
arXiv, 2026Preprint
Paper Project
Classification of narcolepsy type 1 using machine learning on Stanford Cataplexy Questionnaire responses and HLA-DQB1∗06:02
Giorgio Ricciardiello Mejia, Andreas Brink-Kjaer & Emmanuel Mignot
Sleep Medicine, 2026
Paper
Dual foundation models for accelerometry predict future health
Marcus Dige, Niels R. Lorenzen, Magnus Ruud Kjær, Angus Burns, Poul Jennum, Emmanuel H. During, James Zou, Emmanuel Mignot & Andreas Brink-Kjaer
medRxiv, 2026Preprint
Part of Foundation models for wrist accelerometry, Accelerometry and future health risk
Paper
Vision-Based Automated Severity Rating of REM Sleep Behavior Disorder: From Heuristic Features to Foundation Models
Jeongyeon Hwang, Nicolas Pesch, Brinda Raval, Mohamed Abdelfattah, Amene Gafsi, Amelia Bertolaso, Kang Hyun Ryu, Salonee Marwaha, Oliver Sum-Ping, Matteo Cesari, Ambra Stefani, Andreas Brink-Kjaer, Emmanuel Mignot, Alexandre Alahi & Emmanuel During
medRxiv, 2026Preprint
Paper
Obstructive apneas immediately impact atrial hemodynamics and arrhythmias
Lisa A. Gottlieb, Katharina Friederichs, Anna Paaske Buhring, Julie Norup Hertel, Charles Ye, Julie Verne Henriksen, Alberte Spange, Nicolai Krohn, Benedikt Linz, Sarah Dalgas Nissen, Laura Bødker Ponsaing, Andreas Brink-Kjaer, Poul Jørgen Jennum, Klaus Fuglsang Kofoed, Dominik Linz & Thomas Jespersen
Heart Rhythm, 2026
Paper
Mechanistic Interpretability of EEG Foundation Models via Sparse Autoencoders
William Lehn-Schiøler, Magnus Ruud Kjær, Rahul Thapa, Magnus Guldberg Pedersen, Anton Mosquera Storgaard, Nick Williams, Radu Gatej, Tue Lehn-Schiøler, Andreas Brink-Kjaer, Sadasivan Puthusserypady, Sándor Beniczky, James Zou & Lars Kai Hansen
arXiv, 2026Preprint
Part of Foundation models for polysomnography
Paper Code
Pretraining on Sleep Data Improves non-Sleep Biosignal Tasks
William Lehn-Schiøler, Magnus Ruud Kjær, Phillip Hempel, Magnus Guldberg Pedersen, Rahul Thapa, Bryan He, Nicolai Spicher, Andreas Brink-Kjaer, Lars Kai Hansen & Emmanuel Mignot
arXiv, 2026Preprint
Paper
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink-Kjaer & Emmanuel H. During
Annals of Clinical and Translational Neurology, 2026
Part of Wearable screening for isolated REM sleep behavior disorder
Paper
Comparison of EMG, Video, and Actigraphy Signals for Detecting Motor Activity in REM Sleep Behavior Disorder
Kang Hyun Ryu, Giorgio Ricciardiello Mejia, Salonee Marwaha, Andreas Brink-Kjaer & Emmanuel H. During
Diagnostics, 2026
Paper
Expert-level probabilistic breathing event detector informs phenotyping of sleep apnea
Magnus Ruud Kjaer, Umaer Hanif, Andreas Brink-Kjaer, Mads Olsen, Oliver Sum-Ping, Oscar Carrillo, Scott A. Sands, Susan Redline, Katie L. Stone, Poul Jennum & Emmanuel Mignot
Nature Communications, 2026
Part of Automated sleep event detection
Paper Code
Local REM sleep-N1-wake sleep stage mixing in narcolepsy type 1
Constantin Weberpals, Adrien Specht, Natasja Bonde Andersen, Mads Olsen, Yves Dauvilliers, Giuseppe Plazzi, Lucie Barateau, Fabio Pizza, Francesco Biscarini, Jing Zhang, Han Yan, Ambra Stefani, Birgit Hogl, Matteo Cesari, Seung Chul Hong, Dmitri Volfson, Poul Jennum, Andreas Brink-Kjaer & Emmanuel Mignot
medRxiv, 2026Preprint
Paper
A multimodal sleep foundation model for disease prediction
Rahul Thapa, Magnus Ruud Kjaer, Bryan He, Ian Covert, Hyatt Moore IV, Umaer Hanif, Gauri Ganjoo, M. Brandon Westover, Poul Jennum, Andreas Brink-Kjaer, Emmanuel Mignot & James Zou
Nature Medicine, 2026
Part of Whole-night sleep biomarkers and phenotyping, Foundation models for polysomnography
Paper Code Dataset News News
AcceleRest: A Physiology-Aware Masked Autoencoder for Wrist Accelerometer-based Sleep Staging and Apnea Evaluation
Niels Rasmus Lorenzen, Andreas Brink-Kjaer, Poul Joergen Jennum & Emmanuel Mignot
medRxiv, 2026Preprint
Part of Foundation models for wrist accelerometry
Paper Code
Sleep Microstructure and Cognitive Trajectories in Healthy Aging: Insights from a Longitudinal Cohort Study
Olalla Urdanibia-Centelles, Sine Kongsbak Arvedsen, Andreas Brink-Kjaer, Martin Lauritzen, Krisztina Benedek & Poul Jennum
SSRN, 2026Preprint
Paper

2025

Stanford Sleep Bench: Evaluating Polysomnography Pre-training Methods for Sleep Foundation Models
Magnus Ruud Kjaer, Rahul Thapa, Gauri Ganjoo, Hyatt Moore, Poul Joergen Jennum, Brandon M. Westover, James Zou, Emmanuel Mignot, Bryan He & Andreas Brink-Kjaer
arXiv, 2025Preprint
Part of Foundation models for polysomnography
Paper Code Dataset
Actigraphy-based detection of isolated REM sleep behavior disorder: multicenter validation across devices and populations
Li Zhou, Andreas Brink-Kjaer, Katarina Gunter, Salonee Marwaha, Ambra Stefani, Birgit Högl, Michele T. Hu, Emmanuel Mignot, Ankit Parekh, Qi Tang, Merve Aktan-Süzgün, Bei Huang, Shi Tang, Siyi Gong, Yuhua Yang, Xie Chen, Jianzhang Ni, Ningning Li, Zhixuan He, Yun Kwok Wing & Emmanuel During
npj Digital Medicine, 2025
Part of Wearable screening for isolated REM sleep behavior disorder
Paper
Isolated REM Sleep Behaviour Disorder—Is Screening Possible?
Matteo Cesari, Andreas Brink-Kjaer, Emmanuel During, Wolfgang Ganglberger, Oriella Gnarra, Bei Huang, Michael Sommerauer, Pietro Luca Ratti, Irene Rechichi, Yun Kwok Wing & Ambra Stefani
Journal of Sleep Research, 2025
Paper
Sleep stage mixing is associated with poor prognosis in early Parkinson’s disease
Pauline Dodet, Emmanuel During, Isabelle Arnulf, Claudia Trenkwalder, Brit Mollenhauer, Friederike Sixel-Döring, Emmanuel Roze, Marie Vidailhet, Thomas Andrillon, Stéphane Lehericy, Jean-Christophe Corvol, Graziella Mangone, Smaranda Leu-Semenescu, Emmanuel Mignot, Poul Jennum & Andreas Brink-Kjaer
npj Parkinson's Disease, 2025
Paper
An important step toward automation of polysomnography analyses
Matteo Cesari, Andreas Brink-Kjaer & Irene Rechichi
Sleep, 2025
Paper
Rapid Eye Movements (REMs) during Non‐REM Sleep as a Marker of Alpha‐Synucleinopathies
Estefania Vargas Gonzalez, Zhongmei Yang, Pauline Dodet, Smaranda Leu‐Semenescu, Andreas Brink-Kjaer, Paul Roujansky, Poul Joergen Jennum, François‐Xavier Lejeune, Marie Vidailhet & Isabelle Arnulf
Movement Disorders, 2025
Paper
Breathing Segmentation for Per Breath Sleep Apnea Detection
Magnus Ruud Kjær, Søren Straarup Rasmussen, Andreas Brink-Kjaer, Poul Jennum & Emmanuel Mignot
IEEE EMBC, 2025
Paper
Modeling Spatial Synchronization of Sleep for Detection of Idiopathic REM Sleep Behavior Disorder
Natasja P. Andersen, Poul J. Jennum, Emmanuel Mignot & Andreas Brink-Kjaer
IEEE EMBC, 2025
Paper
Frequency-Aware Masked Autoencoders for Human Activity Recognition using Accelerometers
Niels R. Lorenzen, Poul J. Jennum, Emmanuel Mignot & Andreas Brink-Kjaer
IEEE EMBC, 2025
Part of Foundation models for wrist accelerometry
Paper Code
Diagnostic performance of actigraphy in Alzheimer’s disease using a machine learning classifier – a cross-sectional memory clinic study
Mathias Holsey Gramkow, Andreas Brink-Kjaer, Frederikke Kragh Clemmensen, Nikolai Sulkjær Sjælland, Gunhild Waldemar, Poul Jennum, Steen Gregers Hasselbalch & Kristian Steen Frederiksen
Alzheimer's Research & Therapy, 2025
Part of Accelerometry and future health risk
Paper
Mortality risk assessment using deep learning-based frequency analysis of electroencephalography and electrooculography in sleep
Teitur Óli Kristjánsson, Katie L Stone, Helge B D Sorensen, Andreas Brink-Kjaer, Emmanuel Mignot & Poul Jennum
Sleep, 2025
Part of Whole-night sleep biomarkers and phenotyping
Paper
Probabilistic sleep staging in MSLTs across hypersomnia disorders
Louise Hjuler Andersen, Andreas Brink-Kjaer, Oliver Sum-Ping, Fabio Pizza, Francesco Biscarini, Niels Christian Haubjerg Østerby, Emmanuel Mignot, Giuseppe Plazzi & Poul J Jennum
Sleep, 2025
Paper
Detection of Gait Alterations Related to Parkinson’s Disease Prior to Diagnosis Using Free-Living Wrist Accelerometer Data
Li Zhou, Ashley Brill, Sajila Wickramaratne, Giorgio Ricciardiello Mejia, Kang Hyun Ryu, Yuguang Xiong, Salonee Marwaha, Katarina Gunter, Ankit Parekh, Fanny M. Elahi, Andreas Brink-Kjaer & Emmanuel H. During
SSRN, 2025Preprint
Part of Gait and motor function from wrist accelerometry
Paper

2023

SViT: A Spectral Vision Transformer for the Detection of REM Sleep Behavior Disorder
Katarina Mary Gunter, Andreas Brink-Kjaer, Emmanuel Mignot, Helge B.D. Sørensen, Emmanuel During & Poul Jennum
IEEE Journal of Biomedical and Health Informatics, 2023
Paper
Detection and Characterization of Walking Bouts Using a Single Wrist-Worn Accelerometer in Free-living Conditions
Andreas Brink-Kjaer, Sajila D. Wickramaratne, Ankit Parekh & Emmanuel H. During
medRxiv, 2023Preprint
Part of Gait and motor function from wrist accelerometry
Paper Code
Fully Automated Detection of Isolated Rapid-Eye-Movement Sleep Behavior Disorder Using Actigraphy
Andreas Brink-Kjaer, Joseph Winer, Jamie M. Zeitzer, Helge B. D. Sorensen, Poul Jennum, Emmanuel Mignot & Emmanuel During
IEEE EMBC, 2023
Paper
The genetic etiology of periodic limb movement in sleep
Jacob L Edelson, Logan D Schneider, David Amar, Andreas Brink-Kjaer, Katie L Cederberg, Zoltán Kutalik, Erika W Hagen, Paul E Peppard, Priscila Farias Tempaku, Sergio Tufik, Daniel S Evans, Katie Stone, Greg Tranah, Brian Cade, Susan Redline, Jose Haba-Rubio, Raphael Heinzer, Pedro Marques-Vidal, Peter Vollenweider, Juliane Winkelmann, James Zou & Emmanuel Mignot
Sleep, 2023
Paper
Ambulatory Detection of Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder Combining Actigraphy and Questionnaire
Andreas Brink-Kjaer, Niraj Gupta, Eric Marin, Jennifer Zitser, Oliver Sum‐Ping, Anahid Hekmat, Flavia Bueno, Ana Cahuas, James Langston, Poul Jennum, Helge B.D. Sorensen, Emmanuel Mignot & Emmanuel During
Movement Disorders, 2023
Part of Wearable screening for isolated REM sleep behavior disorder
Paper

2022

End-to-end Deep Learning of Polysomnograms for Classification of REM Sleep Behavior Disorder
Andreas Brink-Kjaer, Katarina Mary Gunter, Emmanuel Mignot, Emmanuel During, Poul Jennum & Helge B.D. Sorensen
IEEE EMBC, 2022
Paper
Age estimation from sleep studies using deep learning predicts life expectancy
Andreas Brink-Kjaer, Eileen B. Leary, Haoqi Sun, M. Brandon Westover, Katie L. Stone, Paul E. Peppard, Nancy E. Lane, Peggy M. Cawthon, Susan Redline, Poul Jennum, Helge B. D. Sorensen & Emmanuel Mignot
npj Digital Medicine, 2022
Part of Whole-night sleep biomarkers and phenotyping
Paper Code Blog
A Model for Estimating Biological Age From Physiological Biomarkers of Healthy Aging: Cross-sectional Study
Karina Louise Skov Husted, Andreas Brink-Kjaer, Mathilde Fogelstrøm, Pernille Hulst, Akita Bleibach, Kaj-Åge Henneberg, Helge Bjarup Dissing Sørensen, Flemming Dela, Jens Christian Brings Jacobsen & Jørn Wulff Helge
JMIR Aging, 2022
Paper

2021

Arousal characteristics in patients with Parkinson’s disease and isolated rapid eye movement sleep behavior disorder
Andreas Brink-Kjaer, Matteo Cesari, Friederike Sixel-Döring, Brit Mollenhauer, Claudia Trenkwalder, Emmanuel Mignot, Helge B D Sorensen & Poul Jennum
Sleep, 2021
Paper
Polysomnographic Plethysmography Excursions are Reduced in Obese Elderly Men
Magnus Ruud Kjar, Andreas Brink-Kjaer, Umaer Hanif, Emmanuel Mignot, Poul Jennum & Helge B. D. Sorensen
IEEE EMBC, 2021
Paper
Cortical arousal frequency is increased in narcolepsy type 1
Andreas Brink-Kjaer, Julie A E Christensen, Matteo Cesari, Emmanuel Mignot, Helge B D Sorensen & Poul Jennum
Sleep, 2021
Paper

2020

A Biological Age Model Designed for Health Promotion Interventions: Protocol for an Interdisciplinary Study for Model Development
Karina Louise Skov Husted, Mathilde Fogelstrøm, Pernille Hulst, Andreas Brink-Kjaer, Kaj-Åge Henneberg, Helge Bjarup Dissing Sorensen, Flemming Dela & Jørn Wulff Helge
JMIR Research Protocols, 2020
Paper
Predicting Age with Deep Neural Networks from Polysomnograms
Andreas Brink-Kjaer, Emmanuel Mignot, Helge B.D. Sorensen & Poul Jennum
IEEE EMBC, 2020
Paper Code
Automatic detection of cortical arousals in sleep and their contribution to daytime sleepiness
Andreas Brink-Kjaer, Alexander Neergaard Olesen, Paul E. Peppard, Katie L. Stone, Poul Jennum, Emmanuel Mignot & Helge B.D. Sorensen
Clinical Neurophysiology, 2020
Part of Automated sleep event detection
Paper Code
Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts
Lorenzo Carvelli, Alexander N. Olesen, Andreas Brink-Kjaer, Eileen B. Leary, Paul E. Peppard, Emmanuel Mignot, Helge B.D. Sørensen & Poul Jennum
Sleep Medicine, 2020
Part of Automated sleep event detection
Paper

2017

Automatic segmentation of vessels in in-vivo ultrasound scans
Philip Tamimi-Sarnikowski, Andreas Brink-Kjaer, Ramin Moshavegh & Jørgen Arendt Jensen
Proc. SPIE, 2017
Paper